Chromosome mapping of human CDC25A and CDC25B phosphatases

Demetrick, D. J., Beach, D. H. (October 1993) Chromosome mapping of human CDC25A and CDC25B phosphatases. Genomics, 18 (1). pp. 144-7. ISSN 0888-7543 (Print)

DOI: 10.1006/geno.1993.1440


The human CDC25 tyrosine phosphatases trigger activation of CDC2 by removing inhibitory phosphates; thus the genes encoding these phosphatases may be suspected as potential oncogenes due to their role in promoting cell division. To date, three human CDC25 genes have been identified: CDC25A, B, and C. This communication describes the mapping of CDC25A to chromosome 3p21 and CDC25B to chromosome 20p13 by fluorescence in situ hybridization with confirmation by the polymerase chain reaction of hamster-human somatic cell hybrid DNA. 3p21 is near an area frequently involved in karyotypic abnormalities in renal carcinomas, small cell carcinomas of the lung, and benign tumors of the salivary gland. 20p13 does not seem to be a common area for karyotypic alteration in tumors. Mapping of these genes to their chromosomal loci may help identify tumors with abnormal regulation of CDC25 genes due to genomic alterations.

Item Type: Paper
Uncontrolled Keywords: Animals Base Sequence Chromosome Mapping Chromosomes, Human, Pair 20 Chromosomes, Human, Pair 3 Cricetinae DNA Primers Humans Hybrid Cells In Situ Hybridization, Fluorescence Molecular Sequence Data Protein-Tyrosine-Phosphatase/ genetics Proteins/ genetics Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. cdc25 Phosphatase
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomes, structure and function
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > protein tyrosine phosphatase
CSHL Authors:
Communities: CSHL labs > Beach lab
Depositing User: Matt Covey
Date: October 1993
Date Deposited: 19 Apr 2016 15:59
Last Modified: 19 Apr 2016 15:59
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