Fission yeast cdc25 is a cell-cycle regulated protein

Ducommun, B., Draetta, G., Young, P., Beach, D. (February 1990) Fission yeast cdc25 is a cell-cycle regulated protein. Biochem Biophys Res Commun, 167 (1). pp. 301-9. ISSN 0006-291X (Print)0006-291X (Linking)

DOI: 10.1016/0006-291X(90)91765-K


Fission yeast cell division is initiated by the cdc2/cdc13-cyclin protein kinase which in its catalytically active state comprises the mitotic inducer. During interphase the cdc2/cyclin complex is assembled in an inactive state that requires cdc25+ gene function for M-phase activation. The cdc25+ product, a 76 kd phosphoprotein, is shown to oscillate in abundance during the cell cycle, reaching a peak at G2/M, and to be sensitive to nitrogen starvation. The level of cdc25 is subject to feedback regulation involving both cdc25 and cdc2.

Item Type: Paper
Uncontrolled Keywords: Blotting, Western Cell Cycle *Cell Cycle Proteins Electrophoresis, Polyacrylamide Gel Escherichia coli/genetics Fungal Proteins/*genetics Gene Expression Genes, Fungal Nitrogen Plasmids Promoter Regions, Genetic Schizosaccharomyces/*genetics *ras-GRF1
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell cycle
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression
organism description > yeast
CSHL Authors:
Communities: CSHL labs > Beach lab
Depositing User: Matt Covey
Date: 28 February 1990
Date Deposited: 04 Apr 2016 14:43
Last Modified: 04 Apr 2016 14:43
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