The spil GTPase interacts with RCCl in cell cycle dependency

Matsumoto, T., Beach, D. (1991) The spil GTPase interacts with RCCl in cell cycle dependency. Cold Spring Harb Symp Quant Biol, 56. pp. 385-98. ISSN 0091-7451 (Print)0091-7451 (Linking)

DOI: 10.1101/SQB.1991.056.01.046


Eukaryotic cell cycles can be broadly classified into two types, those that display dependency and those that do not. In a dependent cycle, sequential events follow, each progressively due to the existence of molecular checkpoints. Failure to complete one event, such as DNA replication, activates a checkpoint mechanism that prevents the onset of subsequent events, such as mitosis. All somatic cells display a variety of such checkpoints that monitor cell growth, DNA replication, DNA repair, and so on (for review, see Hartwell and Weinert 1989). However, in embryos, particularly those that accumulate a substantial cell mass during oogenesis, such checkpoints are cryptic, and the division cycle is usually very rapid and may occur without appreciable cell growth (Kimelman et al. 1987).

Item Type: Paper
Uncontrolled Keywords: Amino Acid Sequence Base Sequence Cell Cycle/genetics/*physiology *Cell Cycle Proteins DNA, Fungal/genetics DNA-Binding Proteins/genetics/*metabolism GTP Phosphohydrolases/genetics/*metabolism Genes, Fungal *Guanine Nucleotide Exchange Factors Molecular Sequence Data Mutation *Nuclear Proteins Phenotype Schizosaccharomyces/cytology/genetics/metabolism Sequence Homology, Nucleic Acid
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > GTPase
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell cycle
CSHL Authors:
Communities: CSHL labs > Beach lab
Depositing User: Matt Covey
Date: 1991
Date Deposited: 10 Dec 2015 21:17
Last Modified: 10 Dec 2015 21:17
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