Matsumoto, T., Beach, D. (1991) The spil GTPase interacts with RCCl in cell cycle dependency. Cold Spring Harb Symp Quant Biol, 56. pp. 385-98. ISSN 0091-7451 (Print)0091-7451 (Linking)
Abstract
Eukaryotic cell cycles can be broadly classified into two types, those that display dependency and those that do not. In a dependent cycle, sequential events follow, each progressively due to the existence of molecular checkpoints. Failure to complete one event, such as DNA replication, activates a checkpoint mechanism that prevents the onset of subsequent events, such as mitosis. All somatic cells display a variety of such checkpoints that monitor cell growth, DNA replication, DNA repair, and so on (for review, see Hartwell and Weinert 1989). However, in embryos, particularly those that accumulate a substantial cell mass during oogenesis, such checkpoints are cryptic, and the division cycle is usually very rapid and may occur without appreciable cell growth (Kimelman et al. 1987).
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Amino Acid Sequence Base Sequence Cell Cycle/genetics/*physiology *Cell Cycle Proteins DNA, Fungal/genetics DNA-Binding Proteins/genetics/*metabolism GTP Phosphohydrolases/genetics/*metabolism Genes, Fungal *Guanine Nucleotide Exchange Factors Molecular Sequence Data Mutation *Nuclear Proteins Phenotype Schizosaccharomyces/cytology/genetics/metabolism Sequence Homology, Nucleic Acid |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > GTPase organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell cycle |
| CSHL Authors: | |
| Communities: | CSHL labs > Beach lab |
| Depositing User: | Matt Covey |
| Date: | 1991 |
| Date Deposited: | 10 Dec 2015 21:17 |
| Last Modified: | 10 Dec 2015 21:17 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/32151 |
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