Anczukow, O., Krainer, A. R. (October 2015) The spliceosome, a potential Achilles heel of MYC-driven tumors. Genome Med, 7 (1). p. 107. ISSN 1756-994X (Electronic)1756-994X (Linking)
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Abstract
Alterations in RNA splicing are frequent in human tumors. Two recent studies of lymphoma and breast cancer have identified components of the spliceosome - the core splicing machinery - that are essential for malignant transformation driven by the transcription factor MYC. These findings provide a direct link between MYC and RNA splicing deregulation, and raise the exciting possibility of targeting spliceosome components in MYC-driven tumors.
| Item Type: | Paper |
|---|---|
| Subjects: | diseases & disorders > cancer bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > Myc bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > spliceosome complex |
| CSHL Authors: | |
| Communities: | CSHL labs > Krainer lab CSHL Cancer Center Program > Gene Regulation and Inheritance Program |
| Depositing User: | Matt Covey |
| Date: | 22 October 2015 |
| Date Deposited: | 27 Oct 2015 18:56 |
| Last Modified: | 26 Oct 2020 20:46 |
| PMCID: | PMC4618744 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/31956 |
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