Zhou, C., Franconville, R., Vaughan, A. G., Robinett, C. C., Jayaraman, V., Baker, B. S. (September 2015) Central neural circuitry mediating courtship song perception in male. Elife, 4. ISSN 2050-084X (Electronic)2050-084X (Linking)
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Abstract
Animals use acoustic signals across a variety of social behaviors, particularly courtship. In Drosophila, song is detected by antennal mechanosensory neurons and further processed by second-order aPN1/aLN(al) neurons. However, little is known about the central pathways mediating courtship hearing. In this study, we identified a male-specific pathway for courtship hearing via third-order ventrolateral protocerebrum Projection Neuron 1 (vPN1) neurons and fourth-order pC1 neurons. Genetic inactivation of vPN1 or pC1 disrupts song-induced male-chaining behavior. Calcium imaging reveals that vPN1 responds preferentially to pulse song with long inter-pulse intervals (IPIs), while pC1 responses to pulse song closely match the behavioral chaining responses at different IPIs. Moreover, genetic activation of either vPN1 or pC1 induced courtship chaining, mimicking the behavioral response to song. These results outline the aPN1-vPN1-pC1 pathway as a labeled line for the processing and transformation of courtship song in males.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | D. melanogaster auditory sensation courtship courtship song neuroscience |
| Subjects: | organism description > animal behavior organism description > animal > gender > male organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits organism description > animal behavior > perception |
| CSHL Authors: | |
| Communities: | CSHL labs > Kepecs lab |
| Depositing User: | Matt Covey |
| Date: | 21 September 2015 |
| Date Deposited: | 25 Sep 2015 15:23 |
| Last Modified: | 16 Jul 2021 14:15 |
| PMCID: | PMC4575990 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/31886 |
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