Karakas, Erkan, Regan, Michael C., Furukawa, Hiro (June 2015) Emerging structural insights into the function of ionotropic glutamate receptors. Trends in Biochemical Sciences, 40 (6). pp. 328-337. ISSN 0968-0004
Abstract
Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that mediate excitatory neurotransmission crucial for brain development and function, including learning and memory formation. Recently a wealth of structural studies on iGluRs including AMPA receptors (AMPARs), kainate receptors, and NMDA receptors (NMDARs) became available. These studies showed structures of non-NMDARs including AMPAR and kainate receptor in various functional states, thereby providing the first visual sense of how non-NMDAR iGluRs may function in the context of homotetramers. Furthermore, they provided the first view of heterotetrameric NMDAR ion channels, and this illuminated the similarities with and differences from non-NMDARs, thus raising a mechanistic distinction between the two groups of iGluRs. We review mechanistic insights into iGluR functions gained through structural studies of multiple groups.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | ionotropic glutamate receptors structural biology pharmacology |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > AMPA receptor bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > NMDA receptor bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > ionotropic glutamate receptor structural biology |
| CSHL Authors: | |
| Communities: | CSHL Post Doctoral Fellows CSHL labs > Furukawa lab Stanley Institute for Cognitive Genomics |
| Depositing User: | Matt Covey |
| Date: | June 2015 |
| Date Deposited: | 07 May 2015 17:03 |
| Last Modified: | 06 Nov 2015 21:20 |
| PMCID: | PMC4464829 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/31491 |
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