Genetic dissection of consolidated memory in Drosophila

Tully, T., Preat, T., Boynton, S. C., Del Vecchio, M. (October 1994) Genetic dissection of consolidated memory in Drosophila. Cell, 79 (1). pp. 35-47. ISSN 0092-8674 (Print)

DOI: 10.1016/0092-8674(94)90398-0


Behavioral and pharmacological experiments in many animal species have suggested that memory is consolidated from an initial, disruptable form into a long-lasting, stable form within a few hours after training. We combined these traditional approaches with genetic analyses in Drosophila to show that consolidated memory of conditioned (learned) odor avoidance 1 day after extended training consisted of two genetically distinct, functionally independent memory components: anesthesia-resistant memory (ARM) and long-term memory (LTM). ARM decayed away within 4 days, was resistant to hypothermic disruption, was insensitive to the protein synthesis inhibitor cycloheximide (CXM), and was disrupted by the radish single-gene mutation. LTM showed no appreciable decay over 7 days, was sensitive to CXM, and was not disrupted by the radish mutation.

Item Type: Paper
Uncontrolled Keywords: Animals Avoidance Learning Brain Chemistry/drug effects Conditioning, Classical Cycloheximide/pharmacology Drosophila/ genetics/physiology Genes, Insect/genetics Memory/drug effects/ physiology Mutation/physiology Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.
Subjects: organism description > animal > insect > Drosophila
organism description > animal behavior > learning
organism description > animal behavior > memory
CSHL Authors:
Communities: CSHL labs > Tully lab
Depositing User: Matt Covey
Date: 7 October 1994
Date Deposited: 27 Aug 2015 13:45
Last Modified: 27 Aug 2015 13:45
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