Tully, T., Preat, T., Boynton, S. C., Del Vecchio, M. (October 1994) Genetic dissection of consolidated memory in Drosophila. Cell, 79 (1). pp. 35-47. ISSN 0092-8674 (Print)
Abstract
Behavioral and pharmacological experiments in many animal species have suggested that memory is consolidated from an initial, disruptable form into a long-lasting, stable form within a few hours after training. We combined these traditional approaches with genetic analyses in Drosophila to show that consolidated memory of conditioned (learned) odor avoidance 1 day after extended training consisted of two genetically distinct, functionally independent memory components: anesthesia-resistant memory (ARM) and long-term memory (LTM). ARM decayed away within 4 days, was resistant to hypothermic disruption, was insensitive to the protein synthesis inhibitor cycloheximide (CXM), and was disrupted by the radish single-gene mutation. LTM showed no appreciable decay over 7 days, was sensitive to CXM, and was not disrupted by the radish mutation.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Animals Avoidance Learning Brain Chemistry/drug effects Conditioning, Classical Cycloheximide/pharmacology Drosophila/ genetics/physiology Genes, Insect/genetics Memory/drug effects/ physiology Mutation/physiology Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. |
| Subjects: | organism description > animal > insect > Drosophila organism description > animal behavior > learning organism description > animal behavior > memory |
| CSHL Authors: | |
| Communities: | CSHL labs > Tully lab |
| Depositing User: | Matt Covey |
| Date: | 7 October 1994 |
| Date Deposited: | 27 Aug 2015 13:45 |
| Last Modified: | 27 Aug 2015 13:45 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/31413 |
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