Joyce, J. A., Fearon, D. T. (April 2015) T cell exclusion, immune privilege, and the tumor microenvironment. Science, 348 (6230). pp. 74-80. ISSN 0036-8075
Abstract
Effective immunotherapy promotes the killing of cancer cells by cytotoxic T cells. This requires not only that cancer-specific T cells be generated, but also that these T cells physically contact cancer cells. The coexistence in some patients of cancer cells and T cells that recognize them indicates that tumors may exhibit the phenomenon of immune privilege, in which immunogenic tissue is protected from immune attack. Here, we review the evidence that stromal cells of the tumor microenvironment mediate this restriction by excluding T cells from the vicinity of cancer cells. Overcoming this T cell checkpoint may thus enable optimal immunotherapy.
| Item Type: | Paper |
|---|---|
| Subjects: | organs, tissues, organelles, cell types and functions > cell types and functions > cell types > T cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > T cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > T cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > immune cell organs, tissues, organelles, cell types and functions > cell types and functions > cell types > immune cell organs, tissues, organelles, cell types and functions > cell types and functions > cell types > immune cell diseases & disorders > cancer > drugs and therapies > tumor microenvironment |
| CSHL Authors: | |
| Communities: | CSHL labs > Fearon lab |
| Depositing User: | Matt Covey |
| Date: | 3 April 2015 |
| Date Deposited: | 17 Apr 2015 15:01 |
| Last Modified: | 17 Apr 2015 15:01 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/31321 |
Actions (login required)
 |
Administrator's edit/view item |