Hiro Furukawa (February 2014) Phenylethanolamine-based NMDA receptor antagonists. United States Patent 8648198. .
Abstract
Described herein are enhanced N-methyl-D-aspartate (NMDA) receptor antagonists, pharmaceutical compositions thereof, and their methods of use and treatment, e.g., of Formula (I):wherein one or more of R1, R2, R3, R4, R5, or the ring formed by the joining of R1 and R2, is a hydrophobic moiety which confers enhanced antagonist activity as compared to existing NMDA receptor antagonists, e.g., ifenprodil. Compounds described herein are designed based on the discovery that ifenprodil binds within the allosteric domain of the GluN1/GluN2B NMDA receptor, particularly at the interface between GluN1 and GluN2B subunits. In silico methods are further described herein.
| Item Type: | Patent |
|---|---|
| Subjects: | patents |
| CSHL Authors: | |
| Communities: | CSHL labs > Furukawa lab |
| Depositing User: | Matt Covey |
| Date: | 11 February 2014 |
| Date Deposited: | 04 Feb 2015 21:40 |
| Last Modified: | 04 Feb 2015 21:40 |
| URI: | https://repository.cshl.edu/id/eprint/31177 |
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