Positive selection on apoptosis related genes

da Fonseca, R. R., Kosiol, C., Vinar, T., Siepel, A., Nielsen, R. (February 2010) Positive selection on apoptosis related genes. FEBS Lett, 584 (3). pp. 469-76. ISSN 0014-5793

URL: http://www.ncbi.nlm.nih.gov/pubmed/20026333
DOI: 10.1016/j.febslet.2009.12.022


Apoptosis is a form of programmed cell death crucial for development, homeostasis, immunity, spermatogenesis, and prevention of cancer. Positive selection acting on mammalian apoptosis related genes targets protein interfaces that interact with pathogens and also elements of signaling complexes. Selection appears primarily to be driven by the immune/defense related function of these genes. Moreover, competitive interactions could be driving positive selection among sperm cells, as well as the need for protection against female anti-sperm immune responses. Trade-offs in fitness are expected out of these selective pressures, which could explain the involvement of these genes in various diseases, including cancer.

Item Type: Paper
Uncontrolled Keywords: Animals Apoptosis/*genetics Evolution, Molecular Female Humans Male Models, Biological Proteins/genetics *Selection, Genetic Signal Transduction/genetics/physiology
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > apoptosis
CSHL Authors:
Communities: CSHL labs > Siepel lab
Depositing User: Matt Covey
Date: 5 February 2010
Date Deposited: 14 Jan 2015 21:52
Last Modified: 14 Jan 2015 21:52
Related URLs:
URI: https://repository.cshl.edu/id/eprint/31058

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