da Fonseca, R. R., Kosiol, C., Vinar, T., Siepel, A., Nielsen, R. (February 2010) Positive selection on apoptosis related genes. FEBS Lett, 584 (3). pp. 469-76. ISSN 0014-5793
Abstract
Apoptosis is a form of programmed cell death crucial for development, homeostasis, immunity, spermatogenesis, and prevention of cancer. Positive selection acting on mammalian apoptosis related genes targets protein interfaces that interact with pathogens and also elements of signaling complexes. Selection appears primarily to be driven by the immune/defense related function of these genes. Moreover, competitive interactions could be driving positive selection among sperm cells, as well as the need for protection against female anti-sperm immune responses. Trade-offs in fitness are expected out of these selective pressures, which could explain the involvement of these genes in various diseases, including cancer.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Animals Apoptosis/*genetics Evolution, Molecular Female Humans Male Models, Biological Proteins/genetics *Selection, Genetic Signal Transduction/genetics/physiology |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > apoptosis |
| CSHL Authors: | |
| Communities: | CSHL labs > Siepel lab |
| Depositing User: | Matt Covey |
| Date: | 5 February 2010 |
| Date Deposited: | 14 Jan 2015 21:52 |
| Last Modified: | 14 Jan 2015 21:52 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/31058 |
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