International Chicken Genome SequencingConsortium, (December 2004) Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution. Nature, 432 (7018). pp. 695-716. ISSN 0028-0836
Abstract
We present here a draft genome sequence of the red jungle fowl, Gallus gallus. Because the chicken is a modern descendant of the dinosaurs and the first non-mammalian amniote to have its genome sequenced, the draft sequence of its genome--composed of approximately one billion base pairs of sequence and an estimated 20,000-23,000 genes--provides a new perspective on vertebrate genome evolution, while also improving the annotation of mammalian genomes. For example, the evolutionary distance between chicken and human provides high specificity in detecting functional elements, both non-coding and coding. Notably, many conserved non-coding sequences are far from genes and cannot be assigned to defined functional classes. In coding regions the evolutionary dynamics of protein domains and orthologous groups illustrate processes that distinguish the lineages leading to birds and mammals. The distinctive properties of avian microchromosomes, together with the inferred patterns of conserved synteny, provide additional insights into vertebrate chromosome architecture.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Animals Avian Proteins/genetics Chickens/*genetics Conserved Sequence/genetics DNA Transposable Elements/genetics *Evolution, Molecular Gene Duplication Genes/genetics *Genome *Genomics Humans Long Interspersed Nucleotide Elements/genetics Multigene Family/genetics Mutagenesis/genetics Physical Chromosome Mapping Pseudogenes/genetics RNA, Untranslated/genetics Retroviridae/genetics Sequence Analysis, DNA Short Interspersed Nucleotide Elements/genetics Synteny Vertebrates/genetics |
| Subjects: | bioinformatics bioinformatics > genomics and proteomics bioinformatics > genomics and proteomics > genetics & nucleic acid processing > genomes Investigative techniques and equipment > assays > whole genome sequencing |
| CSHL Authors: | |
| Communities: | CSHL labs > Siepel lab |
| Depositing User: | Matt Covey |
| Date: | 9 December 2004 |
| Date Deposited: | 15 Jan 2015 20:13 |
| Last Modified: | 15 Jan 2015 20:13 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/31052 |
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