Enikolopov, G., Guillermier, C., Wang, M., Trakimas, L., Steinhauser, M. L., Lechene, C. (November 2014) Brain stem cell division and maintenance studied using multi-isotope imaging mass spectrometry (MIMS). Surface and Interface Analysis, 46 (S1). pp. 140-143. ISSN 01422421
Abstract
New neurons are continuously produced from neural stem cells in specific regions of the adult brain of animals and humans. In the hippocampus, a region crucial for cognitive function, neurogenesis responds to a multitude of extrinsic stimuli; emerging evidence indicates that it may be important for behavior, pathophysiology, brain repair, and response to drugs. We have developed an approach to identify and quantify the cellular targets of pro- and anti-neurogenic stimuli, based on reporter transgenicmouse lines in which neural stemand progenitor cells or their progeny aremarked by fluorescent proteins. Here, we demonstrate the feasibility of using multi-isotope imaging mass spectrometry for studying adult neurogenesis.
| Item Type: | Paper |
|---|---|
| Additional Information: | Meeting Abstract |
| Uncontrolled Keywords: | 15N-thymidine 81Br BrdU DNA synthesis Hippocampus MIMS Multi-isotope imagingmass spectrometry NanoSIMS Neurogenesis SIMS Stable isotope Stemcell division |
| Subjects: | organs, tissues, organelles, cell types and functions > organs types and functions > brain organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell division Investigative techniques and equipment > spectroscopy > mass spectrometry Publication Type > Meeting Abstract |
| CSHL Authors: | |
| Communities: | CSHL labs > Enikopolov lab |
| Depositing User: | Matt Covey |
| Date: | 1 November 2014 |
| Date Deposited: | 19 Dec 2014 18:02 |
| Last Modified: | 21 Dec 2023 19:17 |
| PMCID: | PMC4566142 |
| URI: | https://repository.cshl.edu/id/eprint/30979 |
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