Zheng, H. W., Ying, H. Q., Wiedemeyer, R., Yan, H. Y., Quayle, S. N., Ivanova, E. V., Paik, J. H., Zhang, H. L., Xiao, Y. H., Perry, S. R., Hu, J., Vinjamoori, A., Gan, B. Y., Sahin, E., Chheda, M. G., Brennan, C., Wang, Y. A., Hahn, W. C., Chin, L., DePinho, R. A. (May 2010) PLAGL2 Regulates Wnt Signaling to Impede Differentiation in Neural Stem Cells and Gliomas. Cancer Cell, 17 (5). pp. 497-509. ISSN 1535-6108
Abstract
A hallmark feature of glioblastoma is its strong self-renewal potential and immature differentiation state, which contributes to its plasticity and therapeutic resistance. Here, integrated genomic and biological analyses identified PLAGL2 as a potent protooncogene targeted for amplification/gain in malignant gliomas. Enhanced PLAGL2 expression strongly suppresses neural stem cell (NSC) and glioma-initiating cell differentiation while promoting their self-renewal capacity upon differentiation induction. Transcriptome analysis revealed that these differentiation-suppressive activities are attributable in part to PLAGL2 modulation of Wnt/beta-catenin signaling. Inhibition of Wnt signaling partially restores PLAGL2-expressing NSC differentiation capacity. The identification of PLAGL2 as a glioma oncogene highlights the importance of a growing class of cancer genes functioning to impart stem cell-like characteristics in malignant cells.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | TUMOR-INITIATING CELLS BETA-CATENIN HUMAN GLIOBLASTOMA SELF-RENEWAL SPORADIC MEDULLOBLASTOMAS PATHWAY ACTIVATION PROGENITOR CELLS BRAIN-TUMORS CANCER-CELLS DISEASE Oncology Cell Biology |
| Subjects: | diseases & disorders > cancer organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > differentiation organs, tissues, organelles, cell types and functions > cell types and functions > cell types > stem cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > stem cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > stem cells |
| CSHL Authors: | |
| Communities: | CSHL labs > Zheng lab |
| Depositing User: | Matt Covey |
| Date: | May 2010 |
| Date Deposited: | 22 Aug 2014 18:51 |
| Last Modified: | 22 Aug 2014 18:51 |
| PMCID: | PMC2900858 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/30700 |
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