Dahmann, C., Futcher, B.
(July 1995)
Specialization of B-type cyclins for mitosis or meiosis in S. cerevisiae.
Genetics, 140 (3).
pp. 957-63.
ISSN 0016-6731 (Print)
Abstract
The CLB1, CLB2, and CLB3 genes encode B-type cyclins important for mitosis in Saccharomyces cerevisiae, while a fourth B-type cyclin gene, CLB4, has no clear role. The effects of homozygous clb mutations on meiosis were examined. Mutants homozygous for clb1 clb3, or for clb1 clb4, gave high levels of sporulation, but produced mainly two-spored asci instead of four-spored asci. The cells had completed meiosis I but not meiosis II, producing viable diploid ascospores. CLB1 and CLB4 seem to be much more important for meiosis than for mitosis and may play some special role in meiosis II. In contrast, CLB2 is important for mitosis but not meiosis. The level of Cdc28-Clb activity may be important in determining whether meiosis II will occur.
| Item Type: |
Paper
|
| Uncontrolled Keywords: |
Centromere
Comparative Study
Cyclins/genetics/ physiology
Diploidy
Genetic Markers
Genotype
Meiosis
Mitosis
Mutagenesis
Research Support, U.S. Gov't, P.H.S.
Saccharomyces cerevisiae/cytology/genetics/ growth & development |
| Subjects: |
organism description > yeast > Saccharomyces
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosome > centromere
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomes, structure and function > chromosome > centromere
organs, tissues, organelles, cell types and functions > organelles, types and functions > meiosis
organs, tissues, organelles, cell types and functions > organelles, types and functions > mitosis
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > mutations > mutagenesis |
| CSHL Authors: |
|
| Communities: |
CSHL labs > Futcher lab |
| Depositing User: |
Jessica Koos
|
| Date: |
July 1995 |
| Date Deposited: |
12 Aug 2014 14:26 |
| Last Modified: |
12 Aug 2014 14:26 |
| PMCID: |
PMC1206679 |
| URI: |
https://repository.cshl.edu/id/eprint/30585 |
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