Monoamine receptors in an animal model of affective disorder

Martin, J. V., Edwards, E., Johnson, J. O., Henn, F. A. (October 1990) Monoamine receptors in an animal model of affective disorder. Journal of Neurochemistry, 55 (4). pp. 1142-8. ISSN 0022-3042

DOI: 10.1111/j.1471-4159.1990.tb03117.x


After a relatively mild course of uncontrollable shocks, two distinct groups of rats can be defined in terms of their performance in learning to escape from a controllable stressor. Response-deficient (RD) rats do not learn to terminate the controllable stressor, whereas nondeficient (ND) rats learn this response as readily as do untreated control rats. The current studies were designed to determine the neurochemical correlates of the behavioral differences between these groups of rats. The major findings concerned postsynaptic beta-adrenergic effects in the hippocampus of RD rats. These included an up-regulation of beta-adrenergic receptors and, in parallel experiments, an increase in the sensitivity of adenylyl cyclase to stimulation by norepinephrine. There was no difference in brain levels of catecholamines between the three groups of rats. A statistically significant increase in levels of 5-hydroxytryptamine was noted in the hippocampus and hypothalamus of RD rats as compared to levels in ND rats, but no significant differences were measured between groups of rats in terms of S1 or S2 serotonergic receptor binding. These results implicate both beta-adrenergic and serotonergic mechanisms in the behavioral deficit caused by uncontrollable shock.

Item Type: Paper
Uncontrolled Keywords: Adenylate Cyclase/metabolism Animals Biogenic Amines/*metabolism Brain/*metabolism Disease Models, Animal Dopamine/metabolism Electroshock *Helplessness, Learned Hydroxyindoleacetic Acid/metabolism Male Mood Disorders/*metabolism Neurotransmitter Agents/*metabolism Norepinephrine/metabolism Organ Specificity Rats Rats, Inbred Strains Receptors, Adrenergic, beta/*metabolism Receptors, Serotonin/*metabolism Serotonin/metabolism
Subjects: diseases & disorders > mental disorders > mood disorders
organism description > animal
organism description > animal behavior
organism description > model organism
CSHL Authors:
Communities: CSHL labs > Henn lab
Depositing User: Matt Covey
Date: October 1990
Date Deposited: 24 Jun 2014 16:41
Last Modified: 24 Jun 2014 16:41
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