Beck, D. W., Vinters, H. V., Hart, M. N., Henn, F. A., Cancilla, P. A. (July 1983) Uptake of adenosine into cultured cerebral endothelium. Brain Research, 271 (1). pp. 180-3. ISSN 0006-8993 (Print)0006-8993 (Linking)
Abstract
Adenosine uptake by cultured cerebral endothelium is a carrier-mediated process. The Km value for adenosine uptake is 5.0 microM and the vmax is 1.15 nmol/min/mg cell protein. The uptake system is inhibited by the adenosine analog 2-chloroadenosine at low adenosine concentrations. The results prove the existence of a nucleoside transport system associated with cerebral capillary endothelium.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | 2-Chloroadenosine Adenosine/analogs & derivatives/*metabolism/pharmacology Animals Biological Transport/drug effects Carbon Radioisotopes/diagnostic use Cell Line Cells, Cultured *Cerebrovascular Circulation/drug effects Dipyridamole/pharmacology Endothelium/drug effects/metabolism Kinetics Mice Papaverine/pharmacology Sucrose/metabolism Tritium/diagnostic use |
| Subjects: | organs, tissues, organelles, cell types and functions > cell types and functions > cell types > endothelium organs, tissues, organelles, cell types and functions > cell types and functions > cell types > endothelium organs, tissues, organelles, cell types and functions > cell types and functions > cell types > endothelium |
| CSHL Authors: | |
| Communities: | CSHL labs > Henn lab |
| Depositing User: | Matt Covey |
| Date: | 18 July 1983 |
| Date Deposited: | 19 Jun 2014 20:44 |
| Last Modified: | 19 Jun 2014 20:44 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/30228 |
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