Yin, J. C., Tully, T. (April 1996) CREB and the formation of long-term memory. Current Opinion in Neurobiology, 6 (2). pp. 264-8. ISSN 0959-4388
Abstract
Cyclic AMP response element binding protein (CREB)-responsive transcription plays a central role in the formation of long-term memory in Drosophila, Aplysia and mice. Agents that disrupt the activity of CREB specifically block the formation of long-term memory, whereas agents that increase the amount or activity of the transcription factor accelerate the process. These results have led to the recent hypothesis that CREB is pivotal in the switch from short-term (protein synthesis independent) to long-term (protein synthesis dependent) memory.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Animals Aplysia/physiology Cyclic AMP/physiology Cyclic AMP Response Element-Binding Protein/genetics/ physiology Drosophila/physiology Genes, Switch Memory/ physiology Mice Mice, Knockout/genetics Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor > CREB organism description > animal > insect > Drosophila bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor > Cyclic AMP organism description > animal behavior > memory |
| CSHL Authors: | |
| Communities: | CSHL labs > Tully lab CSHL labs > Yin lab |
| Depositing User: | Kathleen Darby |
| Date: | April 1996 |
| Date Deposited: | 12 May 2014 17:14 |
| Last Modified: | 12 May 2014 17:14 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/30127 |
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