Genetics of apoptosis

Desnoyers, S., Hengartner, M. O. (1997) Genetics of apoptosis. Advances in Pharmacology, 41. pp. 35-56. ISSN 1054-3589 (Print)

DOI: 10.1016/S1054-3589(08)61053-4


The genetic analysis of apoptosis, or programmed cell death, provides important information on the biology of naturally occurring cell death. Identification of genes regulating apoptosis has confirmed that this process follows a similar paradigm in all multicellular organisms. The genetic study of programmed cell death in the invertebrates Caenorhabditis elegans and Drosophila melanogaster has led to the identification of genes regulating this process. These genes function in many different steps of the apoptotic program—for example, initiation, execution of the death sentence, and removal of the cell corpses. Homologs of these cell death genes have been found in higher eukaryotes, suggesting that this process is conserved through evolution. This chapter focuses on advances in understanding of apoptosis achieved through the use of genetic tools. Special emphasis is given on classical genetic model systems such as C. eleguns, Drosophila, mice, and viruses. Genetic studies in C. elegans were the first to show that cell death might be under the control of specific “death” genes. The knowledge gained from the genetics of apoptosis is of upmost importance because it is likely to help in understanding the molecular mechanisms underlying all cell suicide.

Item Type: Paper
Uncontrolled Keywords: Adenoviridae/genetics Animals Apoptosis/ genetics Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.
Subjects: bioinformatics > genomics and proteomics
organism description > virus > adenovirus
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > apoptosis
CSHL Authors:
Communities: CSHL labs > Hengartner lab
Depositing User: Kathleen Darby
Date: 1997
Date Deposited: 07 May 2014 20:14
Last Modified: 07 May 2014 20:14
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