Henry, R. W., Ford, E., Mital, R., Mittal, V., Hernandez, N.
(1998)
Crossing the line between RNA polymerases: transcription of human snRNA genes by RNA polymerases II and III.
Cold Spring Harbor Symposia on Quantitative Biology, 63.
pp. 111-20.
ISSN 00917451 (ISSN)
Abstract
In eukaryotic organisms, transcription is carried out bythree RNA polymerases, RNA polymerases I, II, and III.In general, these RNA polymerases recognize promoterswith very different structures. For example, RNA polymerase II (pol II) promoters are mostly located upstreamof the transcription start site, whereas RNA polymeraseIII (pol III) promoters are mostly located downstreamfrom the transcription start site. The U1, U2, and U6small nuclear RNA (snRNA) genes, which encode essential RNA components of small nuclear ribonucleoproteinparticles (snRNPs) involved in mRNA splicing, serve asrepresentative models for a group of pol II and pol IIIgenes with unusually similar promoters. The pol II U1and U2 promoters contain a distal sequence element(DSE) and a proximal sequence element (PSE), whereasthe pol III U6 promoter contains a DSE, a PSE, and aTATA box, all located upstream of the transcriptionalstart sit...
| Item Type: |
Paper
|
| Uncontrolled Keywords: |
Amino Acid Sequence
Humans
Molecular Sequence Data
Promoter Regions (Genetics)
Protein Biosynthesis
RNA Polymerase II/ metabolism
RNA Polymerase III/ metabolism
RNA, Small Nuclear/ genetics
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Transcription Factors/chemistry/ metabolism
Transcription, Genetic |
| Subjects: |
bioinformatics > genomics and proteomics > design > amino acid design
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > transcription
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > RNA polymerase
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > snRNA
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor |
| CSHL Authors: |
|
| Communities: |
CSHL labs > Hernandez lab
CSHL labs > Mittal lab |
| Depositing User: |
Kathleen Darby
|
| Date: |
1998 |
| Date Deposited: |
01 May 2014 17:55 |
| Last Modified: |
07 May 2014 13:13 |
| Related URLs: |
|
| URI: |
https://repository.cshl.edu/id/eprint/29893 |
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