Giese, K. P., Storm, J. F., Reuter, D., Fedorov, N. B., Shao, L. R., Leicher, T., Pongs, O., Silva, A. J. (September 1998) Reduced K+ channel inactivation, spike broadening, and after-hyperpolarization in Kvbeta1.1-deficient mice with impaired learning. Learning and Memory, 5 (4-5). pp. 257-73. ISSN 1072-0502 (Print)
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Abstract
A-type K+ channels are known to regulate neuronal firing, but their role in repetitive firing and learning in mammals is not well characterized. To determine the contribution of the auxiliary K+ channel subunit Kvbeta1.1 to A-type K+ currents and to study the physiological role of A-type K+ channels in repetitive firing and learning, we deleted the Kvbeta1.1 gene in mice. The loss of Kvbeta1.1 resulted in a reduced K+ current inactivation in hippocampal CA1 pyramidal neurons. Furthermore, in the mutant neurons, frequency-dependent spike broadening and the slow afterhyperpolarization (sAHP) were reduced. This suggests that Kvbeta1.1-dependent A-type K+ channels contribute to frequency-dependent spike broadening and may regulate the sAHP by controlling Ca2+ influx during action potentials. The Kvbeta1.1-deficient mice showed normal synaptic plasticity but were impaired in the learning of a water maze test and in the social transmission of food preference task, indicating that the Kvbeta1.1 subunit contributes to certain types of learning and memory.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Action Potentials/physiology Animals Calcium/physiology Cues Evoked Potentials/ physiology Food Preferences Hippocampus/pathology/ physiology/physiopathology Kv1.1 Potassium Channel Large-Conductance Calcium-Activated Potassium Channel beta Subunits Learning Disorders/genetics/pathology/ physiopathology Maze Learning/ physiology Mice Mice, Knockout Neuronal Plasticity Potassium Channels/deficiency/genetics/ physiology Potassium Channels, Voltage-Gated Pyramidal Cells/pathology/ physiology Research Support, Non-U.S. Gov't Social Behavior Synapses/physiology |
| Subjects: | organs, tissues, organelles, cell types and functions > tissues types and functions > hippocampus organism description > animal behavior > learning organism description > animal behavior > memory organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > pyramidal neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > pyramidal neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > pyramidal neurons organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > synapse |
| CSHL Authors: | |
| Communities: | CSHL labs |
| Depositing User: | Kathleen Darby |
| Date: | September 1998 |
| Date Deposited: | 01 May 2014 19:40 |
| Last Modified: | 01 May 2014 19:40 |
| PMCID: | PMC311244 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/29883 |
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