Braus, D. F., Ende, G., Weber-Fahr, W., Sartorius, A., Krier, A., Hubrich-Ungureanu, P., Ruf, M., Stuck, S., Henn, F. A. (August 1999) Antipsychotic drug effects on motor activation measured by functional magnetic resonance imaging in schizophrenic patients. Schizophrenia Research, 39 (1). pp. 19-29. ISSN 0920-9964 (Print)
Abstract
Brain function and laterality in schizophrenia were investigated by means of a simple motor task with a self-generated left-hand sequential finger opposition (SFO) using a whole-brain high-speed (100 ms per slice) functional imaging technique. Neuroleptic-naive, acutely ill schizophrenic patients were compared to schizophrenic patients under stable neuroleptic medication and matched controls. The goal was to evaluate both the motor function in first-episode patients and possible effects of different neuroleptic treatments on functional MRI results. Forty patients satisfying ICD 10 criteria (F20.x) for schizophrenia and sex- and age-matched healthy volunteers participated in this study. All subjects underwent fMRI examinations on a conventional 1.5 T MR unit. The primary sensorimotor cortex and the high-order supplementary motor area (SMA) were evaluated. There was a close similarity in the activation of the primary and high-order (SMA) sensorimotor areas between first-episode schizophrenic patients and controls. In contrast, a significant reduction in the overall blood oxygen level dependent (BOLD) response was seen in sensorimotor cortices (contra- and ipsilateral) in schizophrenic patients under stable medication with typical neuroleptics. This effect was not present in patients treated with atypical antipsychotics. Both antipsychotic treatments, however, led to a significant reduction in activation of the SMA region compared to controls and neuroleptic-naive subjects. Thus, the present study provides no evidence for the localized involvement of the primary motor cortex or the SMA as a relatively stable vulnerability marker in schizophrenia. There is, however, strong evidence that neuroleptics themselves influence fMRI activation patterns and that there are major differences between typical neuroleptics and atypical antipsychotics.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Adult Antipsychotic Agents/ adverse effects Clozapine/ adverse effects Female Humans Magnetic Resonance Imaging Male Motor Cortex/ anatomy & histology/ drug effects/physiopathology Oxygen/blood Psychomotor Performance/ drug effects Risperidone/ adverse effects Schizophrenia/diagnosis/ drug therapy/physiopathology Somatosensory Cortex/ anatomy & histology/ drug effects/physiopathology |
| Subjects: | diseases & disorders diseases & disorders > mental disorders > schizophrenia Investigative techniques and equipment > magnetic resonance imaging organs, tissues, organelles, cell types and functions > tissues types and functions > somatosensory cortex |
| CSHL Authors: | |
| Communities: | CSHL labs > Henn lab |
| Depositing User: | Kathleen Darby |
| Date: | 23 August 1999 |
| Date Deposited: | 23 Apr 2014 17:41 |
| Last Modified: | 23 Apr 2014 18:00 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/29839 |
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