Wallace-Brodeur, R. R., Lowe, S. W.
(January 1999)
Clinical implications of p53 mutations.
Cellular and Molecular Life Sciences , 55 (1).
pp. 64-75.
ISSN 1420-682X (Print)
Abstract
The ultimate goal of basic cancer research is to provide a theoretical foundation for rational approaches to improve cancer therapy. Our extensive insight into the biology of the p53 tumour suppressor and the clinical behaviour of tumours harbouring p53 mutations indicates that information concerning p53 will be useful in diagnosis and prognosis, and may ultimately produce new therapeutic strategies. At the same time, efforts to understand the clinical implications of p53 mutations have revealed conceptual and technical limitations in translating basic biology to the clinic. The lessons learned from p53 may lay the groundwork for future efforts to synthesize cancer gene function, cancer genetics and cancer therapy.
| Item Type: |
Paper
|
| Uncontrolled Keywords: |
Antineoplastic Agents/toxicity
Apoptosis/genetics
Cell Cycle/genetics
Drug Resistance/genetics
Genes, Tumor Suppressor/genetics
Genes, p53/ genetics
Humans
Mutation/ genetics
Neoplasms/diagnosis/ genetics/therapy
Protein Binding/genetics
Research Support, U.S. Gov't, P.H.S. |
| Subjects: |
diseases & disorders > neoplasms
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell cycle
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > mutations
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > p53
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types |
| CSHL Authors: |
|
| Communities: |
CSHL labs > Lowe lab |
| Depositing User: |
Kathleen Darby
|
| Date: |
January 1999 |
| Date Deposited: |
30 Apr 2014 14:23 |
| Last Modified: |
30 Apr 2014 14:23 |
| Related URLs: |
|
| URI: |
https://repository.cshl.edu/id/eprint/29797 |
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