Postnatal synaptic potentiation: Delivery of GluR4-containing AMPA receptors by spontaneous activity

Zhu, J. J., Esteban, J. A., Hayashi, Y., Malinow, R. (November 2000) Postnatal synaptic potentiation: Delivery of GluR4-containing AMPA receptors by spontaneous activity. Nature Neuroscience, 3 (11). pp. 1098-1106. ISSN 1097-6256

URL: http://www.ncbi.nlm.nih.gov/pubmed/11036266

DOI: 10.1038/80614

Abstract

To examine how functional circuits are established in the brain, we studied excitatory transmission in early postnatal hippocampus. Spontaneous neural activity was sufficient to selectively deliver GluR4-containing AMPA receptors (AMPA-Rs) into synapses. This delivery allowed non-functional connections to transmit at resting potentials and required NMDA receptors (NMDA-Rs) but not CaMKII activation. Subsequently, these delivered receptors were exchanged with non-synaptic GluR2-containing AMPA-Rs in a manner requiring little neuronal activity. The enhanced transmission resulting from this delivery and subsequent exchange was maintained for at least several days and required an interaction between GluR2 and NSF. Thus, this sequence of subunit-specific trafficking events triggered by spontaneous activity in early postnatal development may be crucial for initial establishment of long-lasting functional circuitry.

Item Type:	Paper
Uncontrolled Keywords:	LONG-TERM POTENTIATION CENTRAL GLUTAMATERGIC SYNAPSE SILENT SYNAPSES NETWORK OSCILLATIONS HIPPOCAMPAL-NEURONS EXCITATORY SYNAPSES NMDA RECEPTOR CA1 REGION IN-VIVO EXPRESSION
Subjects:	bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > AMPA receptor bioinformatics > genomics and proteomics > small molecules > Glutamate bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > glutamate receptor organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > synapse organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > synaptic transmission
CSHL Authors:	Esteban, Jose Malinow, Roberto Zhu, J. Julius Hayashi, Yasunori
Communities:	CSHL labs > Malinow lab
Depositing User:	Matt Covey
Date:	November 2000
Date Deposited:	30 Jan 2014 15:35
Last Modified:	30 Jan 2014 15:35
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/29431

Actions (login required)

Administrator's edit/view item