Hengartner, M. O. (October 2000) The biochemistry of apoptosis. Nature, 407 (6805). pp. 770-776. ISSN 0028-0836
DOI: 10.1038/35037710
Abstract
Apoptosis - the regulated destruction of a cell - is a complicated process. The decision to die cannot be taken lightly, and the activity of many genes influence a cell's likelihood of activating its self-destruction programme. Once the decision is taken, proper execution of the apoptotic programme requires the coordinated activation and execution of multiple subprogrammes. Here I review the basic components of the death machinery, describe how they interact to regulate apoptosis in a coordinated manner, and discuss the main pathways that are used to activate cell death.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | PROGRAMMED CELL-DEATH BCL-X-L INDUCED-PROXIMITY MODEL CYTOCHROME-C CASPASE ACTIVATION NMR STRUCTURE COMPLEX FAMILY MITOCHONDRIA PROTEINS |
| Subjects: | organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > apoptosis |
| CSHL Authors: | |
| Communities: | CSHL labs > Hengartner lab |
| Depositing User: | Matt Covey |
| Date: | October 2000 |
| Date Deposited: | 31 Jan 2014 16:25 |
| Last Modified: | 31 Jan 2014 16:25 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/29358 |
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