Giese, K. P., Friedman, E., Telliez, J. B., Fedorov, N. B., Wines, M., Feig, L. A., Silva, A. J. (November 2001) Hippocampus-dependent learning and memory is impaired in mice lacking the Ras-guanine-nucleotide releasing factor 1 (Ras-GRF1). Neuropharmacology, 41 (6). pp. 791-800. ISSN 0028-3908
Abstract
Previous results have suggested that the Ras signaling pathway is involved in learning and memory. Ras is activated by nucleotide exchange factors, such as the calmodulin-activated guanine-nucleotide releasing factor 1 (Ras-GRF1). To test whether Ras-GRF1 is required for learning and memory, we inactivated the Ras-GRF1 gene in mice. These mutants performed normally in a rota-rod motor coordination task, and in two amygdala-dependent tasks (inhibitory avoidance and contextual conditioning). In contrast the mutants were impaired in three hippocampus-dependent learning tasks: contextual discrimination, the social transmission of food preferences, and the hidden-platform version of the Morris water maze. These studies indicate that Ras-GRF1 plays a role in hippocampal-dependent learning and memory. (C) 2001 Elsevier Science Ltd. All rights reserved.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | amygdala gene targeting hippocampus learning mutant mouse Ras signaling LONG-TERM-MEMORY PROTEIN-MEDIATED SIGNALS EXCHANGE FACTOR DORSAL HIPPOCAMPUS KINASE CASCADE IMPRINTED GENE ACTIVATION FEAR LESIONS GRF |
| Subjects: | organs, tissues, organelles, cell types and functions > tissues types and functions > hippocampus organism description > animal behavior > learning organism description > animal behavior > memory bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > G protein > Ras |
| CSHL Authors: | |
| Communities: | CSHL labs |
| Depositing User: | Matt Covey |
| Date: | November 2001 |
| Date Deposited: | 22 Jan 2014 17:58 |
| Last Modified: | 22 Jan 2014 17:58 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/29238 |
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