Shusterman, R., Smear, M. C., Koulakov, A. A., Rinberg, D. (August 2011) Precise olfactory responses tile the sniff cycle. Nature Neuroscience, 14 (8). 1039-U136. ISSN 1097-6256
Abstract
In terrestrial vertebrates, sniffing controls odorant access to receptors, and therefore sets the timescale of olfactory stimuli. We found that odorants evoked precisely sniff-locked activity in mitral/tufted cells in the olfactory bulb of awake mouse. The trial-to-trial response jitter averaged 12 ms, a precision comparable to other sensory systems. Individual cells expressed odor-specific temporal patterns of activity and, across the population, onset times tiled the duration of the sniff cycle. Responses were more tightly time-locked to the sniff phase than to the time after inhalation onset. The spikes of single neurons carried sufficient information to discriminate odors. In addition, precise locking to sniff phase may facilitate ensemble coding by making synchrony relationships across neurons robust to variation in sniff rate. The temporal specificity of mitral/tufted cell output provides a potentially rich source of information for downstream olfactory areas.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | BULB UNIT-ACTIVITY ODOR REPRESENTATIONS TEMPORAL PRECISION SPIKE TRAINS TUFTED CELLS CORTEX RAT INFORMATION INHIBITION ACCURACY |
| Subjects: | Investigative techniques and equipment > electrophysiology organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > tissues types and functions > olfactory bulb organs, tissues, organelles, cell types and functions > tissues types and functions |
| CSHL Authors: | |
| Communities: | CSHL labs > Koulakov lab |
| Depositing User: | Matt Covey |
| Date: | August 2011 |
| Date Deposited: | 19 Dec 2013 19:45 |
| Last Modified: | 19 Dec 2013 19:45 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/29122 |
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