Jacob, Y., Martienssen, R. (June 2012) Molecular biology. All packed up and ready to go. Science, 336 (6087). pp. 1391-1392. ISSN 0036-8075
Preview |
PDF
Martienssen_Science_2012.pdf - Other Download (148kB) | Preview |
Abstract
In eukaryotes, the two states of chromatin were first distinguished cytologically according to their different levels of condensation. Euchromatin has an open conformation that correlates with an active state of gene expression, whereas the transcriptionally silent heterochromatin is tightly packaged. On page 1448 of this issue, Moissiard et al. describe the identification of proteins that are specifically required for the condensed structure of heterochromatin in flowering plants (1). And on page 1445 of this issue, Qian et al. (2) identify a plant protein that binds to biochemically modified DNA and itself modifies histones to generate a chromatin state that allows active DNA demethylation (and gene expression).
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | directed dna methylation organization pathway genome |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > DNA methylation bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification bioinformatics > genomics and proteomics > genetics & nucleic acid processing bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > Chromatin dynamics bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > Chromatin dynamics > heterochromatin |
| CSHL Authors: | |
| Communities: | CSHL labs > Martienssen lab |
| Depositing User: | Matt Covey |
| Date: | June 2012 |
| Date Deposited: | 13 Dec 2013 16:50 |
| Last Modified: | 19 Jul 2021 20:40 |
| PMCID: | PMC4844340 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/28979 |
Actions (login required)
 |
Administrator's edit/view item |