Gruntman, E., Turner, G. C. (October 2013) Integration of the olfactory code across dendritic claws of single mushroom body neurons. Nature Neuroscience, 16 (12). pp. 1821-1829. ISSN 10976256
Abstract
In the olfactory system, sensory inputs are arranged in different glomerular channels, which respond in combinatorial ensembles to the various chemical features of an odor. We investigated where and how this combinatorial code is read out deeper in the brain. We exploited the unique morphology of neurons in the Drosophila mushroom body, which receive input on large dendritic claws. Imaging odor responses of these dendritic claws revealed that input channels with distinct odor tuning converge on individual mushroom body neurons. We determined how these inputs interact to drive the cell to spike threshold using intracellular recordings to examine mushroom body responses to optogenetically controlled input. Our results provide an elegant explanation for the characteristic selectivity of mushroom body neurons: these cells receive different types of input and require those inputs to be coactive to spike. These results establish the mushroom body as an important site of integration in the fly olfactory system.
| Item Type: | Paper |
|---|---|
| Subjects: | organism description > animal behavior organs, tissues, organelles, cell types and functions > tissues types and functions > mushroom body organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organism description > animal behavior > olfactory organs, tissues, organelles, cell types and functions > tissues types and functions |
| CSHL Authors: | |
| Communities: | CSHL labs > Turner lab School of Biological Sciences > Publications |
| Depositing User: | Matt Covey |
| Date: | October 2013 |
| Date Deposited: | 11 Nov 2013 21:01 |
| Last Modified: | 23 Dec 2014 21:02 |
| PMCID: | PMC3908930 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/28855 |
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