Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23

Li, J., Yang, Y., Peng, Y., Austin, R. J., van Eyndhoven, G., Nguyen, K. C. Q., Gabriele, T., McCurrach, M. E., Marks, J. R., Hoey, T., Lowe, S. W., Powers, S. (June 2002) Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23. Nature Genetics, 31 (2). pp. 133-134. ISSN 1061-4036

URL: http://www.ncbi.nlm.nih.gov/pubmed/12021784

DOI: 10.1038/ng888

Abstract

We found that PPM1D, encoding a serine/threonine protein phosphatase, lies within an epicenter of the region at 17q23 that is amplified in breast cancer. We show that overexpression of this gene confers two oncogenic phenotypes on cells in culture: attenuation of apoptosis induced by serum starvation and transformation of primary cells in cooperation with RAS.

Item Type:	Paper
Subjects:	diseases & disorders > cancer diseases & disorders > cancer > cancer types > breast cancer bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > oncogene
CSHL Authors:	Lowe, Scott W. McCurrach, Mila E. Powers, Scott
Communities:	CSHL labs > Lowe lab CSHL labs > Powers lab
Depositing User:	Matt Covey
Date:	June 2002
Date Deposited:	08 Jan 2014 17:42
Last Modified:	25 Feb 2014 16:03
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/28733

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