Klar, A. J. S., Strathern, J. N., Hicks, J. B. (1981) A position-effect control for gene transposition: State of expression of yeast mating-type genes affects their ability to switch. Cell, 25 (2). pp. 517-524.
Abstract
Mating-type switches of the yeast Saccharomyces cerevisiae occur by unidirectional transposition of copies of unexpressed mating-type genetic information, residing at HML and HMR loci, into the expressed MAT locus. The HML and HMR loci remain unchanged. In contrast, in appropriate strains where the silent loci are also allowed to express, for example in mar mutants, efficient switches of HML and HMR are shown to occur at rates equivalent to those observed for MAT. Thus the position-effect control on the direction of transposition is affected by the state of expression of the locus under study; the expressed loci switch regardless of their location.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | radioisotope animal experiment fungus gene expression heredity in vitro study mating type position effect saccharomyces cerevisiae transposon Crosses, Genetic DNA Restriction Enzymes DNA, Fungal Gene Expression Regulation Mutation Recombination, Genetic Support, U.S. Gov't, P.H.S. |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > transposons organism description > yeast |
| CSHL Authors: | |
| Communities: | CSHL labs > Hicks lab |
| Depositing User: | Matt Covey |
| Date: | 1981 |
| Date Deposited: | 09 Aug 2013 20:56 |
| Last Modified: | 12 Aug 2013 14:24 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/28484 |
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