O'Donnell, M., Langston, L., Stillman, B. (July 2013) Principles and concepts of DNA replication in bacteria, archaea, and eukarya. Cold Spring Harbor Perspectives in Biology, 5 (7). ISSN 19430264
Abstract
The accurate copying of genetic information in the double helix of DNA is essential for inheritance of traits that define the phenotype of cells and the organism. The core machineries that copy DNA are conserved in all three domains of life: bacteria, archaea, and eukaryotes. This article outlines the general nature of the DNA replication machinery, but also points out important and key differences. The most complex organisms, eukaryotes, have to coordinate the initiation of DNA replication from many origins in each genome and impose regulation that maintains genomic integrity, not only for the sake of each cell, but for the organism as a whole. In addition, DNA replication in eukaryotes needs to be coordinated with inheritance of chromatin, developmental patterning of tissues, and cell division to ensure that the genome replicates once per cell division cycle.
| Item Type: | Paper |
|---|---|
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > DNA replication bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification bioinformatics > genomics and proteomics > genetics & nucleic acid processing organism description > bacteria organs, tissues, organelles, cell types and functions > cell types and functions > cell types > eukaryote organs, tissues, organelles, cell types and functions > cell types and functions > cell types > eukaryote organs, tissues, organelles, cell types and functions > cell types and functions > cell types > eukaryote |
| CSHL Authors: | |
| Communities: | CSHL labs > Stillman lab |
| Highlight: | Stillman, Bruce W. |
| Depositing User: | Matt Covey |
| Date: | July 2013 |
| Date Deposited: | 19 Jul 2013 16:18 |
| Last Modified: | 20 Jun 2017 16:24 |
| PMCID: | PMC3685895 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/28459 |
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