Kamalakaran, Sitharthan, Varadan, Vinay, Janevski, Angel, Banerjee, Nilanjana, Tuck, David, McCombie, Richard, Dimitrova, Nevenka, Harris, Lyndsay N. (August 2013) Translating Next Generation Sequencing to practice: opportunities and necessary steps. Molecular Oncology, 7 (4). pp. 743-755. ISSN 1574-7891
Abstract
Abstract Next-generation sequencing (NGS) approaches for measuring RNA and DNA benefit from greatly increased sensitivity, dynamic range and detection of novel transcripts. These technologies are rapidly becoming the standard for molecular assays and represent huge potential value to the practice of oncology. However, many challenges exist in the transition of these technologies from research application to clinical practice. This review discusses the value of NGS in detecting mutations, copy number changes and RNA quantification and their applications in oncology, the challenges for adoption and the relevant steps that are needed for translating this potential to routine practice.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Next Generation Sequencing Oncology personalized medicine genomics |
| Subjects: | diseases & disorders > cancer bioinformatics > genomics and proteomics > genetics & nucleic acid processing bioinformatics > genomics and proteomics bioinformatics > genomics and proteomics > genetics & nucleic acid processing > genomes Investigative techniques and equipment > assays > next generation sequencing bioinformatics > genomics and proteomics > personal genomes bioinformatics > genomics and proteomics > genetics & nucleic acid processing > genomes > personal genomes |
| CSHL Authors: | |
| Communities: | CSHL labs > McCombie lab |
| Depositing User: | Matt Covey |
| Date: | August 2013 |
| Date Deposited: | 22 May 2013 20:51 |
| Last Modified: | 19 Jul 2021 13:57 |
| PMCID: | PMC5528427 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/28319 |
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