Martienssen, R. A. (November 2003) Maintenance of heterochromatin by RNA interference of tandem repeats. Nature Genetics, 35 (3). pp. 213-4. ISSN 1061-4036
DOI: 10.1038/ng1252
Abstract
Tandem repeats are prone to epigenetic silencing regulated by RNA interference. This may be because siRNAs from tandem array transcripts are regenerated by RNA-dependent RNA polymerase (RdRP) and Dicer, but siRNAs from single-copy sequences are exhausted by sequential use of downstream primers by RdRP. This could account for the formation of heterochromatin from tandem repeats.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Heterochromatin genetics RNA Interference Tandem Repeat Sequences |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification bioinformatics > genomics and proteomics > genetics & nucleic acid processing bioinformatics > genomics and proteomics bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNAi bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > Chromatin dynamics |
| CSHL Authors: | |
| Communities: | CSHL labs > Martienssen lab |
| Depositing User: | Matt Covey |
| Date: | November 2003 |
| Date Deposited: | 28 Mar 2013 13:48 |
| Last Modified: | 28 Mar 2013 13:48 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/28003 |
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