Carlton, J. M., Hirt, R. P., Silva, J. C., Delcher, A. L., Schatz, M., Zhao, Q., Wortman, J. R., Bidwell, S. L., Alsmark, U. C. M., Besteiro, S., Sicheritz-Ponten, T., Noel, C. J., Dacks, J. B., Foster, P. G., Simillion, C., Van De Peer, Y., Miranda-Saavedra, D., Barton, G. J., Westrop, G. D., Müller, S., Dessi, D., Fiori, P. L., Ren, Q., Paulsen, I., Zhang, H., Bastida-Corcuera, F. D., Simoes-Barbosa, A., Brown, M. T., Hayes, R. D., Mukherjee, M., Okumura, C. Y., Schneider, R., Smith, A. J., Vanacova, S., Villalvazo, M., Haas, B. J., Pertea, M., Feldblyum, T. V., Utterback, T. R., Shu, C. L., Osoegawa, K., De Jong, P. J., Hrdy, I., Horvathova, L., Zubacova, Z., Dolezal, P., Malik, S. B., Logsdon Jr, J. M., Henze, K., Gupta, A., Wang, C. C., Dunne, R. L., Upcroft, J. A., Upcroft, P., White, O., Salzberg, S. L., Tang, P., Chiu, C. H., Lee, Y. S., Embley, T. M., Coombs, G. H., Mottram, J. C., Tachezy, J., Fraser-Liggett, C. M., Johnson, P. J. (2007) Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis. Science, 315 (5809). pp. 207-212. ISSN 00368075 (ISSN)
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Abstract
We describe the genome sequence of the protist Trichomonas vaginalis, a sexually transmitted human pathogen. Repeats and transposable elements comprise about two-thirds of the ∼160-megabase genome, reflecting a recent massive expansion of genetic material. This expansion, in conjunction with the shaping of metabolic pathways that likely transpired through lateral gene transfer from bacteria, and amplification of specific gene families implicated in pathogenesis and phagocytosis of host proteins may exemplify adaptations of the parasite during its transition to a urogenital environment. The genome sequence predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | metronidazole tinidazole bacterium gene transfer genome microbial activity parasite transmission pathogen protein protozoan article drug mechanism gene amplification gene sequence genome analysis mitochondrion nonhuman nucleotide repeat oxidative stress pathogenesis phagocytosis priority journal RNA processing sexually transmitted disease Trichomonas vaginalis trichomoniasis Animals Biological Transport DNA Transposable Elements DNA, Protozoan Gene Transfer, Horizontal Genes, Protozoan Genome, Protozoan Humans Hydrogen Metabolic Networks and Pathways Molecular Sequence Data Multigene Family Organelles Peptide Hydrolases Protozoan Proteins Repetitive Sequences, Nucleic Acid RNA Processing, Post-Transcriptional Sequence Analysis, DNA Sexually Transmitted Diseases Trichomonas Infections Protista |
| Subjects: | bioinformatics bioinformatics > genomics and proteomics > genetics & nucleic acid processing bioinformatics > genomics and proteomics bioinformatics > genomics and proteomics > genetics & nucleic acid processing > genomes |
| CSHL Authors: | |
| Communities: | CSHL labs > Schatz lab |
| Depositing User: | Matt Covey |
| Date: | 2007 |
| Date Deposited: | 15 Mar 2013 18:13 |
| Last Modified: | 03 Oct 2019 13:46 |
| PMCID: | PMC2080659 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/27826 |
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