Henn, F. A., Vollmayr, B. (November 2004) Basic pathophysiological mechanisms in depression: what are they and how might they affect the course of the illness? Pharmacopsychiatry, 37 Sup. S152-6. ISSN 0176-3679 (Print)0176-3679 (Linking)
Abstract
Basic pathophysiological mechanisms in affective disorders are discussed. Studies carried out suggest that changes in neurogenesis do not underlie the behavioral changes which lead to helplessness. Since the behavioral changes leading to depressive or anxious behaviors are not correlated with changes in neurogenesis it appears unlikely that a decrease in the rate of neurogenesis is the basis for depression. A modified gene expression resulting in both functional and structural brain changes remains the most consistent hypothesis to explain how affective disorders may occur. An alternative candidate, synaptogenesis, appears as a likely candidate and requires further experimental testing.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Brain/pathology/ physiopathology Depression/pathology/ physiopathology Humans Hypothalamo-Hypophyseal System/physiopathology Nerve Net/pathology/ physiopathology Neurotransmitter Agents/physiology Pituitary-Adrenal System/physiopathology |
| Subjects: | diseases & disorders diseases & disorders > mental disorders diseases & disorders > mental disorders > mood disorders diseases & disorders > mental disorders > mood disorders > depression |
| CSHL Authors: | |
| Communities: | CSHL labs > Henn lab |
| Depositing User: | Matt Covey |
| Date: | November 2004 |
| Date Deposited: | 04 Mar 2013 21:09 |
| Last Modified: | 04 Mar 2013 21:09 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/27719 |
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