Henn, F. A., Vollmayr, B. (August 2004) Neurogenesis and depression: etiology or epiphenomenon? Biol Psychiatry, 56 (3). pp. 146-50. ISSN 0006-3223 (Print)0006-3223 (Linking)
Abstract
The concept that decreased neurogenesis might be the cause of depression is supported by the effects of stress on neurogenesis and the demonstration that neurogenesis seems to be necessary for antidepressant action. Data from the animal models tested to date show that decreasing the rate of neurogenesis does not lead to depressive behavior. Furthermore, evidence shows that an effective treatment for depression, transcranial magnetic stimulation, does not alter rates of neurogenesis. On the basis of these findings, it is suggested that neurogenesis might play a subtle role in depression but that it is not the primary factor in the final common pathway leading to depression.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Animals Antidepressive Agents/therapeutic use Brain/ pathology Cell Division/physiology Depression/drug therapy/epidemiology/ etiology Disease Models, Animal Humans Neurons/ pathology Stress, Physiological/drug therapy/physiopathology Time Factors |
| Subjects: | diseases & disorders diseases & disorders > mental disorders diseases & disorders > mental disorders > mood disorders diseases & disorders > mental disorders > mood disorders > depression |
| CSHL Authors: | |
| Communities: | CSHL labs > Henn lab |
| Depositing User: | Matt Covey |
| Date: | 1 August 2004 |
| Date Deposited: | 04 Mar 2013 20:30 |
| Last Modified: | 04 Mar 2013 20:30 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/27707 |
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