Bolduc, F. V., Bell, K. G., Cox, H., Broadie, K. S., Tully, T. (October 2008) Excess protein synthesis in Drosophila Fragile X mutants impairs long-term memory. Nat Neurosci, 11 (10). 1143 - 1145 .
DOI: 10.1038/nn.2175
Abstract
We used Drosophila olfactory memory as a model to study the molecular basis of cognitive defects in Fragile X syndrome in vivo. We observed that fragile X protein was acutely required and interacted with argonaute1 and staufen in the formation of long-term memory. Occlusion of long-term memory formation in Fragile X mutants could be rescued by protein synthesis inhibitors, suggesting that excess baseline protein synthesis could negatively affect cognition.
| Item Type: | Paper |
|---|---|
| Subjects: | diseases & disorders > congenital hereditary genetic diseases diseases & disorders organism description > animal > insect > Drosophila diseases & disorders > congenital hereditary genetic diseases > fragile X syndrome organism description > animal > insect organism description > animal behavior > memory |
| CSHL Authors: | |
| Communities: | CSHL labs > Tully lab School of Biological Sciences > Publications |
| Depositing User: | Matt Covey |
| Date: | October 2008 |
| Date Deposited: | 26 Feb 2013 20:30 |
| Last Modified: | 22 Sep 2014 15:48 |
| PMCID: | PMC3038669 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/27526 |
Actions (login required)
 |
Administrator's edit/view item |