A splicing component adapted to gene silencing

Roca, X., Krainer, A. R. (March 2009) A splicing component adapted to gene silencing. Nat Biotechnol, 27 (3). pp. 250-1. ISSN 1546-1696 (Electronic)1087-0156 (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/19270672

DOI: 10.1038/nbt0309-250

Abstract

Methods for gene silencing, such as RNA interference1 and antisense2, have transformed the study of molecular, cellular and organismal biology and opened up new therapeutic opportunities. In this issue, Gunderson and colleagues3, present an alternative technology for reducing gene expression based on approx25-nucleotide sequences called U1 adaptors. This approach could be applied to genes that are refractory to silencing by current methods or could be used in combination with other methods to achieve greater silencing potency...

Item Type:	Paper
Uncontrolled Keywords:	Alternative Splicing Combinatorial Chemistry Techniques Gene Silencing RNA, Messenger/genetics/metabolism Ribonucleoproteins, Small Nuclear/genetics/ metabolism
Subjects:	bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification bioinformatics > genomics and proteomics > genetics & nucleic acid processing bioinformatics > genomics and proteomics bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene silencing bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNA splicing bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > RNP
CSHL Authors:	Krainer, Adrian R. Roca, Xavier
Communities:	CSHL labs > Krainer lab
Depositing User:	Matt Covey
Date:	March 2009
Date Deposited:	19 Feb 2013 17:26
Last Modified:	19 Feb 2013 17:26
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/27458

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