Makino, H., Malinow, R. (2011) Compartmentalized versus global synaptic plasticity on dendrites controlled by experience. Neuron, 72 (6). pp. 1001-1011. ISSN 08966273 (ISSN)
Abstract
Synapses in the brain are continuously modified by experience, but the mechanisms are poorly understood. In vitro and theoretical studies suggest threshold-lowering interactions between nearby synapses that favor clustering of synaptic plasticity within a dendritic branch. Here, a fluorescently tagged AMPA receptor-based optical approach was developed permitting detection of single-synapse plasticity in mouse cortex. Sensory experience preferentially produced synaptic potentiation onto nearby dendritic synapses. Such clustering was significantly reduced by expression of a phospho-mutant AMPA receptor that is insensitive to threshold-lowering modulation for plasticity-driven synaptic incorporation. In contrast to experience, sensory deprivation caused homeostatic synaptic enhancement globally on dendrites. Clustered synaptic potentiation produced by experience could bind behaviorally relevant information onto dendritic subcompartments; global synaptic upscaling by deprivation could equally sensitize all dendritic regions for future synaptic input. © 2011 Elsevier Inc.
| Item Type: | Paper |
|---|---|
| Subjects: | organism description > animal behavior organs, tissues, organelles, cell types and functions > cell types and functions > cell functions organs, tissues, organelles, cell types and functions > cell types and functions organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > neural plasticity organs, tissues, organelles, cell types and functions |
| CSHL Authors: | |
| Communities: | CSHL labs > Malinow lab School of Biological Sciences > Publications |
| Depositing User: | Matt Covey |
| Date: | 2011 |
| Date Deposited: | 06 Feb 2013 21:19 |
| Last Modified: | 22 Sep 2014 20:08 |
| PMCID: | PMC3310180 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/27160 |
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