The persistence of a silent memory

Zaratiegui, M., Martienssen, R. (February 2012) The persistence of a silent memory. Nature genetics, 44 (2). pp. 118-9. ISSN 1546-1718 (Electronic)1061-4036 (Linking)

Abstract

One of the most striking properties of RNA interference (RNAi) in Caenorhabditis elegans is its persistence in offspring after the triggering double-stranded RNA (dsRNA) has disappeared. A new study reveals that a heterochromatic silencing mark is deposited around the targets of RNAi and is transmitted through generations. These results show that RNAi can induce stable and heritable chromatin modifications in animals.

Item Type:	Paper
Uncontrolled Keywords:	Animals Caenorhabditis elegans metabolism Caenorhabditis elegans Proteins metabolism Histones metabolism Lysine metabolism RNA Small Interfering metabolism
Subjects:	organism description > animal > C elegans bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification bioinformatics > genomics and proteomics > genetics & nucleic acid processing bioinformatics > genomics and proteomics Investigative techniques and equipment bioinformatics > genomics and proteomics > design > nucleic acid design Investigative techniques and equipment > RNAI bioinformatics > genomics and proteomics > design > nucleic acid design > RNAI Design bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNAi organism description > animal
CSHL Authors:	Martienssen, Robert A. Zaratiegui, Mikel
Communities:	CSHL labs > Martienssen lab
Depositing User:	Matt Covey
Date:	February 2012
Date Deposited:	17 Jan 2013 17:52
Last Modified:	20 Jul 2021 14:54
PMCID:	PMC5556923
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/27092

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