Bernstein, E., Denli, A. M., Hannon, G. J. (2001) The rest is silence. RNA, 7 (11). pp. 1509-1521. ISSN 13558382 (ISSN)
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Abstract
Over the past several years, RNAi and its related phenomena have emerged not only as a powerful experimental tool but also as a new mode of gene regulation. Through a combination of genetic and biochemical approaches we have learned much about the mechanisms underlying dsRNA responces. However, many of the most intriguing aspects of dsRNA-induced gene silencing have yet to be illuminated. What has become abundantly clear is that the complex and highly conserved biology underlying RNA interference is critical both for genome maintenance and for the development of complex organisms. However, it seems probable that we have only begun to reveal the diversity of biological roles played by RNAi-related process.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | double stranded RNA Caenorhabditis elegans gene amplification gene silencing genetic analysis genome Neurospora crassa nonhuman plant priority journal review RNA analysis sequence homology transcription regulation transgene Animals RNA Processing, Post-Transcriptional RNA, Double-Stranded RNA, Small Interfering RNA, Untranslated Transgenes |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification bioinformatics > genomics and proteomics > genetics & nucleic acid processing Investigative techniques and equipment Investigative techniques and equipment > RNAI bioinformatics > genomics and proteomics > design > nucleic acid design > RNAI Design bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNAi |
| CSHL Authors: | |
| Communities: | CSHL labs > Hannon lab School of Biological Sciences > Publications |
| Depositing User: | Matt Covey |
| Date: | 2001 |
| Date Deposited: | 09 Jan 2013 16:54 |
| Last Modified: | 09 Nov 2017 21:28 |
| PMCID: | PMC1370194 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/26473 |
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