RNA interference

Hannon, G. J. (2002) RNA interference. Nature, 418 (6894). pp. 244-251. ISSN 00280836 (ISSN)

Abstract

A conserved biological response to double-stranded RNA, known variously as RNA interference (RNAi) or post-transcriptional gene silencing, mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes. RNAi has been cultivated as a means to manipulate gene expression experimentally and to probe gene function on a whole-genome scale.

Item Type:	Paper
Uncontrolled Keywords:	Genetic engineering Nucleic acids Gene silencing RNA double stranded RNA nucleic acid gene controlled study gene control gene expression gene function genetic transcription genome nonhuman parasite pathogenesis priority journal protein expression review Animals Genetic Techniques Models, Genetic RNA Processing, Post-Transcriptional RNA, Double-Stranded
Subjects:	bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification Investigative techniques and equipment Investigative techniques and equipment > RNAI bioinformatics > genomics and proteomics > design > nucleic acid design > RNAI Design bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNAi
CSHL Authors:	Hannon, Gregory J.
Communities:	CSHL labs > Hannon lab
Depositing User:	Matt Covey
Date:	2002
Date Deposited:	09 Jan 2013 16:56
Last Modified:	09 Jan 2013 16:56
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/26467

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