Hubner, M. R., Spector, D. L. (2010) Role of H3K27 Demethylases Jmjd3 and UTX in Transcriptional Regulation. Cold Spring Harbor Symposia on Quantitative Biology, 75. pp. 43-49. ISSN 00917451 (ISSN)
![[thumbnail of Paper]](https://repository.cshl.edu/style/images/fileicons/application_pdf.png) |
PDF (Paper)
Spector CSHSQB 2010.pdf - Published Version Restricted to CSHL Campus Only Download (2MB) |
Abstract
The influence of histone amino-terminal covalent modifications on gene regulation has drawn intense research efforts in recent years. It is now clear that activating and inactivating modifications have a key role in determining the gene-expression profile of an individual cell or cell lineage. Thus, differences in these modifications have a pivotal role in determining and maintaining cell fate during development. The interplay of histone methyltransferases (HMTs) and demethylases confers the plasticity necessary for changes in the gene-expression profile of a cell during differentiation or changes following environmental cues. The histone H3 lysine 27 (H3K27) demethylases Jmjd3 and UTX remove the gene-inactivating H3K27 dimethyl and trimethyl marks and are involved in inducing and/or maintaining gene expression. In this chapter, we highlight the role of the H3K27 demethylases Jmjd3 and UTX in gene expression.
| Item Type: | Paper |
|---|---|
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > transcription |
| CSHL Authors: | |
| Communities: | CSHL labs > Spector lab |
| Depositing User: | Matt Covey |
| Date: | 2010 |
| Date Deposited: | 10 Dec 2012 20:03 |
| Last Modified: | 28 Jan 2015 15:58 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/26367 |
Actions (login required)
 |
Administrator's edit/view item |