Eukaryotic regulatory RNAs: an answer to the 'genome complexity' conundrum

Prasanth, K. V. , Spector, D. L. (2007) Eukaryotic regulatory RNAs: an answer to the 'genome complexity' conundrum. Genes & Development, 21 (1). pp. 11-42. ISSN 0890-9369

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Abstract

A large portion of the eukaryotic genome is transcribed as noncoding RNAs (ncRNAs). While once thought of primarily as "junk," recent studies indicate that a large number of these RNAs play central roles in regulating gene expression at multiple levels. The increasing diversity of ncRNAs identified in the eukaryotic genome suggests a critical nexus between the regulatory potential of ncRNAs and the complexity of genome organization. We provide an overview of recent advances in the identification and function of eukaryotic ncRNAs and the roles played by these RNAs in chromatin organization, gene expression, and disease etiology.

Item Type: Paper
Uncontrolled Keywords: Eukaryotic Cells Genome, Human Humans RNA, Untranslated
Subjects: bioinformatics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNA expression
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNA replication
CSHL Authors:
Communities: CSHL labs > Spector lab
Depositing User: Matt Covey
Date: 2007
Date Deposited: 10 Dec 2012 20:02
Last Modified: 28 Jan 2015 21:22
Related URLs:
URI: https://repository.cshl.edu/id/eprint/26360

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