Temporal structure in neuronal activity during working memory in macaque parietal cortex

Pesaran, B., Pezaris, J. S., Sahani, M., Mitra, P. P., Andersen, R. A. (2002) Temporal structure in neuronal activity during working memory in macaque parietal cortex. Nature Neuroscience, 5 (8). pp. 805-811. ISSN 10976256 (ISSN)

URL: https://www.ncbi.nlm.nih.gov/pubmed/12134152
DOI: 10.1038/nn890


Many cortical structures have elevated firing rates during working memory, but it is not known how the activity is maintained. To investigate whether reverberating activity is important, we studied the temporal structure of local field potential (LFP) activity and spiking from area LIP in two awake macaques during a memory-saccade task. Using spectral analysis, we found spatially tuned elevated power in the gamma band (25-90 Hz) in LFP and spiking activity during the memory period. Spiking and LFP activity were also coherent in the gamma band but not at lower frequencies. Finally, we decoded LFP activity on a single-trial basis and found that LFP activity in parietal cortex discriminated between preferred and anti-preferred direction with approximately the same accuracy as the spike rate and predicted the time of a planned movement with better accuracy than the spike rate. This finding could accelerate the development of a cortical neural prosthesis.

Item Type: Paper
Uncontrolled Keywords: accuracy animal experiment article cell activity cell structure controlled study Macaca male nerve cell membrane potential nonhuman parietal lobe priority journal saccadic eye movement spectroscopy spike wave task performance working memory Action Potentials Animals Macaca mulatta Memory Short-Term Neurons Photic Stimulation Saccades Signal Processing Computer-Assisted Wakefulness
Subjects: organism description > animal behavior > memory
organism description > animal > mammal > primates
CSHL Authors:
Communities: CSHL labs > Mitra lab
Depositing User: CSHL Librarian
Date: 2002
Date Deposited: 02 Apr 2012 20:15
Last Modified: 06 Feb 2017 20:47
Related URLs:
URI: https://repository.cshl.edu/id/eprint/25870

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