Llinas, R. R., Ribary, U., Jeanmonod, D., Kronberg, E., Mitra, P. P. (December 1999) Thalamocortical dysrhythmia: A neurological and neuropsychiatric syndrome characterized by magnetoencephalography. Proceedings of the National Academy of Sciences, 96 (26). pp. 15222-15227.
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Abstract
Spontaneous magnetoencephalographic activity was recorded in awake, healthy human controls and in patients suffering from neurogenic pain, tinnitus, Parkinson's disease, or depression. Compared with controls, patients showed increased low-frequency rhythmicity, in conjunction with a widespread and marked increase of coherence among high- and low-frequency oscillations. These data indicate the presence of a thalamocortical dysrhythmia, which we propose is responsible for all the above mentioned conditions. This coherent activity, the result of a resonant interaction between thalamus and cortex, is due to the generation of low-threshold calcium spike bursts by thalamic cells. The presence of these bursts is directly related to thalamic cell hyperpolarization, brought about by either excess inhibition or disfacilitation. The emergence of positive clinical symptoms is viewed as resulting from ectopic -band activation, which we refer to as the "edge effect." This effect is observable as increased coherence between low- and high-frequency oscillations, probably resulting from inhibitory asymmetry between high- and low-frequency thalamocortical modules at the cortical level.
| Item Type: | Paper |
|---|---|
| Subjects: | diseases & disorders > nervous system diseases and disorders Investigative techniques and equipment > electrophysiology organism description > animal > mammal > primates > hominids > human Investigative techniques and equipment > imaging |
| CSHL Authors: | |
| Communities: | CSHL labs > Mitra lab |
| Depositing User: | CSHL Librarian |
| Date: | 2 December 1999 |
| Date Deposited: | 04 Apr 2012 19:33 |
| Last Modified: | 10 Sep 2019 19:38 |
| PMCID: | PMC24801 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/25848 |
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