Scott, R., Bourtchuladze, R., Gossweiler, S., Dubnau, J. T., Tully, T. (August 2002) CREB and the discovery of cognitive enhancers. Journal of Molecular Neuroscience, 19 (1-2). pp. 171-177. ISSN 0895-8696
Abstract
In the past few years, a series of molecular-genetic, biochemical, cellular and behavioral studies in fruit flies, sea slugs and mice have confirmed a long-standing notion that long-term memory formation depends on the synthesis of new proteins. Experiments focused on the cAMP-responsive transcription factor, CREB, have established that neural activity-induced regulation of gene transcription promotes a synaptic growth process that strengthens the connections among active neurons. This process constitutes a physical basis for the engram-and CREB is a "molecular switch" to produce the engram. Helicon Therapeutics has been formed to identify drug compounds that enhance memory formation via augmentation of CREB biochemistry. Candidate compounds have been identified from a high throughput cell-based screen and are being evaluated in animal models of memory formation. Agene discovery program also seeks to identify new genes, which function downstream of CREB during memory formation, as a source for new drug discoveries in the future. Together, these drug and gene discovery efforts promise new class of pharmaceutical therapies for the treatment of various forms of cognitive dysfunction.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Cognitive dysfunction Alzheimers disease high throughput screen gene mutant Drosophila mouse |
| Subjects: | diseases & disorders > mental disorders > delirium dementia cognitive disorders therapies organism description > animal behavior > memory |
| CSHL Authors: | |
| Communities: | CSHL labs > Dubnau lab CSHL labs > Tully lab |
| Depositing User: | Brian Soldo |
| Date: | August 2002 |
| Date Deposited: | 22 Mar 2012 16:26 |
| Last Modified: | 09 Apr 2013 16:13 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/25423 |
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